INFLAMMATION: Basic Notes & Emphasis on Periodontics

The inflammatory response has many players. These include circulating cells and plasma proteins, vascular wall cells and extra cellular matrix and its cells in the surrounding connective tissue. While the inflammatory response involves a complex set of highly orchestrated events, the broad outlines are as follows: An initial inflammatory stimulus triggers the release of chemical mediators from plasma or connective tissue cells. Such soluble mediators, acting together or in sequence, amplify the initial inflammatory response and influence its evolution by regulating the subsequent vascular and cellular responses. The inflammatory response is terminated when the injurious stimulus is removed and the inflammatory mediators have been dissipated, catabolised or inhibited.