NON STERIODAL ANTI-INFLAMMATORY DRUGS: IN PERIODONTICS

Bacteria and bacterial products have been considered for a century to be primary importance in the etiology of various forms of destructive periodontal diseases, and have been the focus of numerous research efforts (Socransky and Haffajee, 1994; Moore and Moore, 1994; Haffajee and Socransky, 1994). Periodontal diseases are specific Gram-negative anaerobic bacterial infections leading to the initial destruction of the soft connective tissue and secondarily the underlying alveolar bone and ligament supporting the teeth. Therefore the development of adjunctive chemotherapeutic approaches such as the use of antibiotics, antiseptics and antimicrobial agents to control the bacterial etiology has drawn much attention in the management of periodontal diseases. However, over the past two decades it has become evident that, although oral microbiota are essential agents, their presence alone is not sufficient to clarify the pathophysiological mechanisms of periodontal tissue destruction